TissUse offers high-value service contracts to create custom solutions for safety evaluation of drugs, cosmetics and chemicals, and pre-clinical human disease modelling. Any new chip design serving customer needs with a specific organ arrangement can be prototyped and produced at short notice due to a proprietary rapid prototyping procedure established at TissUse.

The versatile TissUse approach addresses multiple organs & tissues to make the right chip for the right assay.

TissUse Multi organ Chip assay

Drug development

Our goal is to deliver the tools to accelerate drug development through these stages together with all the scientists over the world towards patient’s benefit. Our experienced team with long-standing expertise in Multi-Organ-Chip assay development (>50 MOC publications) will design your flexible, efficient and reliable assay for safety or efficacy testing.

  • Safety: Identify hazards before moving on to exposing organisms with your substance of interest.
  • Efficacy: Get early and strong indication of your substance performance early in the development process.

Examples of established assays by TissUse

  DMPK / Safety / Hazard identification
  Mode of Action / Efficacy

Nr. Organ model Schematic Context of use Level of readiness Species
1 Bone marrow Bone marrow toxicity III
2 Hair follicle Hair growth agents III
3 Skin – Liver Hazard identification, Tier 3 III
4 Intestine – Liver Absorption, metabolism III
5 Lung – Liver Hazard identification III
6 Liver – Pancreas Diabetes drug substances III
7 Skin – Tumor Anti-tumor antibodies III
8 Thyroid – Liver Hazard identification, safety II vs.
9 Testis – Liver Testicular toxicity II
10 Liver – Neuro Metabolite neurotoxicity II
11 Skin – Leukocytes Allograft rejection therapies II
12 Intestine – Muscle Muscle growth agents II vs.
13 vasc. Pancreas – Tumor Anti-tumor therapy II
14 Bone Nanoparticle toxicity I
15 Bone marrow Erythropoiesis I
16 Skin – Hair follicles Hair growth agents I
17 Liver – Cardio Metabolite cardiotox I
18 Liver – Kidney Kidney toxicity I
19 Skin – Lymph node Hazard identification, Tier 3 I
20 vasc. Intestine – Lymph node – Tumor Immuno-Oncology I
21 ADME-axis + 1 ADME-profile, PBPK, Tox I
22 Blood-Brain-Barrier Permeability, Neurotoxicity I

III  Assay established, available for testing/assay transfer
II   Model established, available for assay development
I    Proof of Concept, available for joint development

Choose your Multi-Organ-Chip and organ combination