Publications – Kidney

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2025, Archives of Toxicology, Human and rat renal proximal tubule in vitro models for ADME applications
Klatt OC, de Brouwer L, Hendriks F, Dehne EM, Ataç Wagegg B, Jennings P, Wilmes A

2025, Toxicology in Vitro, Vol. 105, A perfused iPSC-derived proximal tubule model for predicting drug-induced kidney injury
Lechtenberg M, Chéneau C, Riquin K, Koenig L, Mota C, Halary F, Dehne EM

2024, Cells, Vol. 13, SARS-CoV-2 Spike Protein Amplifies the Immunogenicity of Healthy Renal Epithelium in the Presence of Renal Cell Carcinoma
Somova M, Simm S, Ehrhardt J, Schoon J, Burchardt M, Pinto PC

2024, Stem Cell Reports, Vol. 19, Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility
Pamies D, Ekert J, Zurich MG, Frey O, Werner S, Piergiovanni M, Freedman BS, Teo AKK, Erfurth H, Reyes DR, Loskill P, Candarlioglu P, Suter-Dick L, Wang S, Hartung T, Coecke S, Stacey GN, Atac Wagegg B, Dehne EM, Pistollato F, Leist M

2024, Scientific reports, Vol. 14, Integrating tumor and healthy epithelium in a micro-physiology multi-compartment approach to study renal cell carcinoma pathophysiology
Somova M, Simm S, Padmyastuti A, Ehrhardt J, Schoon J, Wolff I, Burchardt M, Roennau C, Caetano Pinto P

2022, Journal of Extracellular Vesicles, Vol. 11, A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles
Nguyen VVT, Ye S, Gkouzioti V, van Wolferen ME, Yengej FY, Melkert D, Siti S, de Jong B, Besseling PJ, Spee B, van der Laan LJW, Horland R, Verhaar MC, van Balkom BWM

2020, Scientific reports, Vol. 10, Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents
Lin N, Zhou X, Geng X, Drewell C, Hübner J, Li Z, Zhang Y, Xue M, Marx U, Li B

2019, Future Science OA, Vol. 5, No. 8, Autologous induced pluripotent stem cell-derived four-organ-chip
Ramme AP, Koenig L, Hasenberg T, Schwenk C, Magauer C, Faust D, Lorenz AK, Krebs AC, Drewell C, Schirrmann K, Vladetic A, Lin GC, Pabinger S, Neuhaus W, Bois F, Lauster R, Marx U, Dehne EM

2015, Lab on a Chip, A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
I Maschmeyer, AK Lorenz, K Schimek, T Hasenberg, AP Ramme, J Hübner, M Lindner, C Drewell, S Bauer, A Thomas, NS Sambo, F Sonntag, R Lauster, U Marx