Publications – Regulatory
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Book chapter | Reviews
2026, NAM Journal, Integrating static and dynamic human in vitro gut-models to assess intestinal absorption, metabolism, and non-specific binding of pesticides
Hallscheidt E, Assbrock L, Hahn M, Kuehnlenz J, Thevis M, Lamshoeft M
2025, ALTEX, Workshop Report: Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare
Marx U, Beken S, Chen Z, Dehne EM, Doherty A, Ewart L, Fitzpatrick SC, Griffith LG, Gu Z, Hartung T, Hickman J, Ingber DE, Ishida S, Jeong J, Leist M, Levin L, Mendrick DL, Pallocca G, Platz S, Raschke M, Smirnova L, Tagle DA, Trapecar M, van Balkom BWM, van den Eijnden-van Raaij J, van der Meer A, Roth A
2024, Stem Cell Reports, Vol. 19, Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility
Pamies D, Ekert J, Zurich MG, Frey O, Werner S, Piergiovanni M, Freedman BS, Teo AKK, Erfurth H, Reyes DR, Loskill P, Candarlioglu P, Suter-Dick L, Wang S, Hartung T, Coecke S, Stacey GN, Atac Wagegg B, Dehne EM, Pistollato F, Leist M
2023, Alternatives to Laboratory Animals, OnlineFirst, Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022
Naik NN, Vadloori B, Poosala S, Srivastava P, Coecke S, Smith A, Akhtar A, Roper C, Radhakrishnan S, Bhyravbhatla B, Damle M, Pulla VK, Hackethal J, Horland R, Li AP, Pati F, Singh MS, Occhetta P, Bisht R, Dandekar P, Bhagavatula K, Pajkrt D, Johnson M, Weber T, Huang J, Hysenaj L, Mallar B, Ramray B, Dixit S, Joshi S, Kulkarni M
2021, Science, Vol. 373, Human microphysiological systems for drug development
Roth A, MPS-WS Berlin 2019
2020, TissUse White Paper, Multi-Organ Microphysiological Systems are Poised for Expansive Integration
2020, ALTEX, Preprint, Biology-inspired Microphysiological systems to advance patient benefit and animal welfare in drug development
Marx U, Akabane T, Andersson T, Baker E, Beilmann M, Beken S, Brendler-Schwaab S, Cirit M, David R, Dehne EM, Durieux I, Ewart L, Fitzpatrick S, Frey O, Fuchs F, Griffith L, Hamilton G, Hartung T, Hoeng J, Hogberg H, Hughes D, Ingber D, Iskandar A, Kanamori T, Kojima H, Kuehnl J, Leist M, Li B, Loskill P, Mendrick D, Neumann T, Pallocca G, Rusyn I, Smirnova L, Steger-Hartmann T, Tagle D, Tonevitsky A, Tsyb S, Trapecar M, van de Water B, van den Eijnden-van Raaij J, Vulto P, Watanabe K, Wolf A, Zhou X, Roth A
2018, ALTEX, Optimizing drug discovery by Investigative Toxicology: Current and future trends
Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T,Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T
2016, ALTEX, Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing = ALTEX Award Winner 2017!
Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A
2015, ALTEX, Workshop Report: Non-Animal Models of Epithelial Barriers (Skin, Intestine and Lung) in Research, Industrial Applications and Regulatory Toxicology
S Gordon, M Daneshian, J Bouwstra, F Caloni, S Constant, DE Davies, G Dandekar, CA Guzman, E Fabian, E Haltner, T Hartung, N Hasiwa, P Hayden, H Kandarova, S Khare, HF Krug, C Kneuer, M Leist, G Lian, U Marx, M Metzger, K Ott, P Prieto, MS Roberts, EL Roggen, T Tralau, C van den Braak, H Walles
2012, Alternatives to Lab Animals, 'Human-on-a-chip' developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?
U Marx, H Walles, S Hoffmann, G Lindner, R Horland, F Sonntag, U Klotzbach, D Sakharov, A Tonevitsky, R Lauster