Publikationen – Leber

2023, Journal of Applied Toxicology, Early View, Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein
Tao TP, Brandmair K, Gerlach S, Przibilla J, Schepky A, Marx U, Hewitt NJ, Maschmeyer I, Kühnl J

2023, Journal of Applied Toxicology, Early View, Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene
Brandmair K, Tao TP, Gerlach S, Przibilla J, Schepky A, Marx U, Hewitt NJ, Kühnl J, Maschmeyer I

2023, bioRxiv, Preprint, Diseased human pancreas and liver microphysiological system for preclinical diabetes research
Rigal S, Casas B, Kanebratt KP, Wennberg Huldt C, Magnusson LU, Mullers E, Karlsson F, Clausen M, Hansson SF, Jansson Lofmark R, Ammala C, Marx U, Gennemark P, Cedersund G, Andersson TB, Vilen LK

2023, Frontiers in Pharmacology, Vol. 14, Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions
Tao TP, Maschmeyer I, LeCluyse EL, Rogers E, Brandmair K, Gerlach S, Przibilla J, Kern F, Genies C, Jacques C, Najjar A, Schepky A, Marx U, Kühnl J, Hewitt NJ

2022, Biomaterials and Biosystems , Vol. 7, Setup of human liver-chips integrating 3D models, microwells and a standardized microfluidic platform as proof-of-concept study to support drug evaluation
Cox B, Barton P, Class R, Coxhead H, Delatour C, Gillent E, Henshall J, Isin EM, King L, Valentin JP

2022, Cells, Vol. 11, A Human Stem Cell-Derived Brain-Liver Chip for Assessing Blood-Brain-Barrier Permeation of Pharmaceutical Drugs
Koenig L, Ramme AP, Faust D, Mayer M, Flötke T, Gerhartl A, Brachner A, Neuhaus W, Appelt-Menzel A, Metzger M, Marx U, Dehne EM

2022, ALTEX, A microfluidic thyroid-liver platform to assess chemical safety in humans
Kühnlenz J, Karwelat D, Steger-Hartmann T, Raschke M, Bauer S, Vural Ö, Marx U, Tinwell H, Bars R

2021, Drug Testing and Analysis, Early view, Organ-on-a-chip: Determine feasibility of a human liver microphysiological model to assess long-term steroid metabolites in sports drug testing
Görgens C, Ramme AP, Guddat S, Schrader Y, Winter A, Dehne EM, Horland R, Thevis M

2021, Journal of Applied Toxicology, Early view, Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model
Tao TP, Brandmair K, Gerlach S, Przibilla J, Géniès C, Jacques‐Jamin C, Schepky A, Marx U, J. Hewitt N, Maschmeyer I, Kühnl J

2021, Toxicology, Vol. 448, Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model
Kühnl J, Tao TP, Brandmair K, Gerlach S, Rings T, Müller-Vieira U, Przibilla J, Genies C, Jaques-Jamin C, Schepky A, Marx U, J. Hewitt N, Maschmeyer I

2020, Scientific reports, Vol. 10, Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents
Lin N, Zhou X, Geng X, Drewell C, Hübner J, Li Z, Zhang Y, Xue M, Marx U, Li B

2020, International Journal of Pharmaceutics, Vol. 589, Toxicity of topically applied drugs beyond skin irritation: Static skin model vs. Two organs-on-a-chip
Tavares RSN, Tao TP, Maschmeyer I, Maria-Engler SS, Schäfer-Korting M, Winter A, Zoschke C, Lauster R, Marx U, Gaspar LR

2020, Human Reproduction, Vol. 35, A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model
Baert Y, Ruetschle I, Cools W, Oehme A, Lorenz A, Marx U, Goossens E, Maschmeyer I

2020, Scientific Reports, Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies
Schimek K, Frentzel S, Luettich K, Bovard D, Rütschle I, Boden L, Rambo F, Erfurth H, Dehne EM, Winter A, Marx U, Hoeng J

2019, Future Science OA, Vol. 5, No. 8, Autologous induced pluripotent stem cell-derived four-organ-chip
Ramme AP, Koenig L, Hasenberg T, Schwenk C, Magauer C, Faust D, Lorenz AK, Krebs AC, Drewell C, Schirrmann K, Vladetic A, Lin GC, Pabinger S, Neuhaus W, Bois F, Lauster R, Marx U, Dehne EM

2017, Nature Scientific Reports, Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model
Bauer S, Wennberg Huldt C, Kanebratt KP, Durieux I, Gunne D, Andersson S, Ewart L, Haynes WG, Maschmeyer I, Winter A, Ämmälä C, Marx U, Andersson TB

2015, Lab on a Chip, A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
I Maschmeyer, AK Lorenz, K Schimek, T Hasenberg, AP Ramme, J Hübner, M Lindner, C Drewell, S Bauer, A Thomas, NS Sambo, F Sonntag, R Lauster, U Marx

2015, European Journal of Pharmaceutics and Biopharmaceutics, Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro
I Maschmeyer, T Hasenberg, A Jaenicke, M Lindner, AK Lorenz, J Zech, LA Garbe, F Sonntag, P Hayden, S Ayehunie, R Lauster, U Marx, EM Materne

2015, Journal of Visualized Experiments, The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
EM Materne, I Maschmeyer, AK Lorenz, R Horland, K Schimek, M Busek, F Sonntag, R Lauster, U Marx

2015, Journal of Biotechnology, A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing
EM Materne, AP Ramme, A Terrasso, M Serra, P Alves, C Brito, D Sakharov, A Tonevitsky, R Lauster, U Marx

2013, Lab on a Chip, Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput
EM Materne, A Tonevitsky, U Marx

2013, Lab on a Chip, A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
I Wagner, EM Materne, S Brincker, U Süßbier, C Frädrich, M Busek, F Sonntag, D Sakharov, E Trushkin, A Tonevitsky, R Lauster, U Marx

2011, BIOspektrum, Miniaturisierte humane organtypische Zell- und Gewebekulturen
F Sonntag, M Gruchow, I Wagner, G Lindner, U Marx

2010, Journal of Biotechnology, Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure
F Sonntag, N Schilling, K Mader, M Gruchow, U Klotzbach, G Lindner, R Horland, I Wagner, R Lauster, S Howitz, S Hoffmann, U Marx