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2020, TissUse White Paper, Multi-Organ Microphysiological Systems are Poised for Expansive Integration

iPSC lines

2021, Stem Cell Research, Vol. 53, Generation of two additional integration-free iPSC lines from related human donors
Ramme AP, Faust D, Koenig L, Nguyen N, Marx U
Cell line repository/bank: Human Pluripotent Stem Cell Registry (hPSCreg)

2019, Stem Cell Research, Vol. 41, Generation of four integration-free iPSC lines from related human donors
Ramme AP, Faust D, Koenig L, Marx U
Cell line repository/bank: Human Pluripotent Stem Cell Registry (hPSCreg)


2020, Elsevier, 441-462, Automation and opportunities for industry scale-up of microphysiological systems in: Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing
Dehne EM, Erfurth H, Muhsmann AK, Marx U

Skin – Liver

2021, Journal of Applied Toxicology, Early view, Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model
Tao TP, Brandmair K, Gerlach S, Przibilla J, Géniès C, Jacques‐Jamin C, Schepky A, Marx U, J. Hewitt N, Maschmeyer I, Kühnl J

2021, Toxicology, Vol. 448, Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model
Kühnl J, Tao TP, Brandmair K, Gerlach S, Rings T, Müller-Vieira U, Przibilla J, Genies C, Jaques-Jamin C, Schepky A, Marx U, J. Hewitt N, Maschmeyer I

2020, International Journal of Pharmaceutics, Vol. 589, Toxicity of topically applied drugs beyond skin irritation: Static skin model vs. Two organs-on-a-chip
Tavares RSN, Tao TP, Maschmeyer I, Maria-Engler SS, Schäfer-Korting M, Winter A, Zoschke C, Lauster R, Marx U, Gaspar LR

2013, Lab on a Chip, A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
I Wagner, EM Materne, S Brincker, U Süßbier, C Frädrich, M Busek, F Sonntag, D Sakharov, E Trushkin, A Tonevitsky, R Lauster, U Marx

Liver – Kidney

2020, Scientific reports, Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents
Lin N, Zhou X, Geng X, Drewell C, Hübner J, Li Z, Zhang Y, Xue M, Marx U, Li B

Hair follicle / Skin Hair follicle

2020, In Vitro Cellular & Developmental Biology – Animal, The microfollicle: a model of the human hair follicle for in vitro studies
Ataç B, Kiss FM, Lam T, Fauler B, Edler C, Hu P, Tao TP, Jädicke M, Rütschle I, Azar RP, Youngquist S, Mielke T, Marx U, Lauster R, Lindner G, DiColandrea T

2020, Journal of Tissue Engineering and Regenerative Medicine, Vol. 14, Reconstructed human skin shows epidermal invagination towards integrated neopapillae indicating early hair follicle formation in vitro
Vahav I, van den Broek LJ, Thon M, Monsuur HN, Spiekstra SW, Atac B, Scheper RJ, Lauster R, Lindner G, Marx U, Gibbs S

2011, BMC Proceedings, Human hair follicle equivalents in vitro for transplantation and chip-based substance testing
R Horland, G Lindner, I Wagner, B Atac, S Hoffmann, M Gruchow, F Sonntag, U Klotzbach, R Lauster, U Marx

2011, Journal of Biotechnology, De novo formation and ultra-structural characterization of a fiber-producing human hair follicle equivalent in vitro
G Lindner, R Horland, I Wagner, B Atac, R Lauster

2011, Experimental Dermatology, Cartilage oligomeric matrix protein (COMP) forms part of the connective tissue of normal human hair follicles
A Ariza de Schellenberger, R Horland, M Rosowski, R Paus, R Lauster, G Lindner


2018, Bioengineering 2018, Bioengineering of a Full-Thickness Skin Equivalent in a 96-Well Insert Format for Substance Permeation Studies and Organ-on-a-Chip Applications
Schimek K, Hsu HH, Boehme M, Kornet JJ, Marx U, Lauster R, Pörtner R, Lindner G

2018, J Vis Exp., A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
Hsu HH, Kracht JK, Harder LE, Rudnik K, Lindner G, Schimek K, Marx U, Pörtner R

Bone marrow

2020, Advanced Science, Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow
Schoon J, Hesse B, Rakow A, Ort MJ, Lagrange A, Jacobi D, Winter A, Huesker K, Reinke S, Cotte M,Tucoulou R, Marx U, Perka C, Duda GN, Geissler S

2019, Current Opinion in Toxicology, Vol. 17, Microphysiological systems in the evaluation of hematotoxicities during drug development
Dehne EM, Winter A, Marx U

2017, J Tissue Eng Regen Med, Bone marrow-on-a-chip: Long term culture of human hematopoietic stem cells in a 3D microfluidic environment
Sieber S, Wirth L, Cavak N, Koenigsmark M, Marx U, Lauster R, Rosowski M

Liver – Testis

2020, Human Reproduction, Vol. 35, A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model
Baert Y, Ruetschle I, Cools W, Oehme A, Lorenz A, Marx U, Goossens E, Maschmeyer I

Lung – Liver

2020, Scientific Reports, Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies
Schimek K, Frentzel S, Luettich K, Bovard D, Rütschle I, Boden L, Rambo F, Erfurth H, Dehne EM, Winter A, Marx U, Hoeng J

Intestine – Liver – Neuro – Kidney

2019, Future Science OA, Vol. 5, No. 8, Autologous induced pluripotent stem cell-derived four-organ-chip
Ramme AP, Koenig L, Hasenberg T, Schwenk C, Magauer C, Faust D, Lorenz AK, Krebs AC, Drewell C, Schirrmann K, Vladetic A, Lin GC, Pabinger S, Neuhaus W, Bois F, Lauster R, Marx U, Dehne EM

Skin – 3D-Tumor

2018, Nature Scientific Reports, Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model
Hübner J, Raschke M, Rütschle I, Gräßle S, Hasenberg T, Schirrmann K, Lorenz A, Schnurre S, Lauster R, Maschmeyer I, Steger-Hartmann T, Marx U


2018, Stem Cell Res Ther., The role of fibrinolysis inhibition in engineered vascular networks derived from endothelial cells and adipose-derived stem cells
Mühleder S, Pill K, Schaupper M, Labuda K, Priglinger E, Hofbauer P, Charwat V, Marx U, Redl H, Holnthoner W

2017, Front. Bioeng. Biotechnol., Engineering Blood and Lymphatic Microvascular Networks in Fibrin Matrices
Knezevic L, Schaupper MV, Muehleder S, Schimek K, Hasenberg T, Marx U, Priglinger E, Redl HR, Holnthoner W

2015, Journal of Biotechnology, Emulating human microcapillaries in a multi-organ-chip platform
T Hasenberg, S Mühleder, A Dotzler, S Bauer, K Labuda, W Holnthoner, H Redl, R Lauster, U Marx

2013, Lab on a Chip, Integrating biological vasculature into a multi-organ-chip microsystem
K Schimek, M Busek, S Brincker, B Groth, S Hoffmann, R Lauster, G Lindner, AK Lorenz, U Menzel, F Sonntag, H Walles, U Marx, R Horland

Liver – Pancreas

2017, Nature Scientific Reports, Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model
Bauer S, Wennberg Huldt C, Kanebratt KP, Durieux I, Gunne D, Andersson S, Ewart L, Haynes WG, Maschmeyer I, Winter A, Ämmälä C, Marx U, Andersson TB

Skin, Intestine, Lung

2015, ALTEX, Workshop Report: Non-Animal Models of Epithelial Barriers (Skin, Intestine and Lung) in Research, Industrial Applications and Regulatory Toxicology
S Gordon, M Daneshian, J Bouwstra, F Caloni, S Constant, DE Davies, G Dandekar, CA Guzman, E Fabian, E Haltner, T Hartung, N Hasiwa, P Hayden, H Kandarova, S Khare, HF Krug, C Kneuer, M Leist, G Lian, U Marx, M Metzger, K Ott, P Prieto, MS Roberts, EL Roggen, T Tralau, C van den Braak, H Walles

Intestine – Liver – Skin – Kidney

2015, Lab on a Chip, A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
I Maschmeyer, AK Lorenz, K Schimek, T Hasenberg, AP Ramme, J Hübner, M Lindner, C Drewell, S Bauer, A Thomas, NS Sambo, F Sonntag, R Lauster, U Marx

Intestine – Liver, Skin – Liver

2015, European Journal of Pharmaceutics and Biopharmaceutics, Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro
I Maschmeyer, T Hasenberg, A Jaenicke, M Lindner, AK Lorenz, J Zech, LA Garbe, F Sonntag, P Hayden, S Ayehunie, R Lauster, U Marx, EM Materne

Skin, Liver, Vasculature

2015, Journal of Visualized Experiments, The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
EM Materne, I Maschmeyer, AK Lorenz, R Horland, K Schimek, M Busek, F Sonntag, R Lauster, U Marx

Liver – Neuro

2015, Journal of Biotechnology, A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing
EM Materne, AP Ramme, A Terrasso, M Serra, P Alves, C Brito, D Sakharov, A Tonevitsky, R Lauster, U Marx

Immune cells – Lymph node / Mesenchymal stromal cells (not Chip)

2014, Advanced Drug Delivery Reviews, Human immunity in vitro - Solving immunogenicity and more
C Giese, U Marx

2012, The International Journal of Artificial Organs, Crosstalk between immune cells and mesenchymal stromal cells in a 3D bioreactor system
M Seifert, A Lubitz, J Trommer, D Könnig, G Korus, U Marx, HD Volk, G Duda, G Kasper, K Lehmann, M Stolk, C Giese

2010, Journal of Biotechnology, Immunological substance testing on human lymphatic micro-organoids in vitro
C Giese, A Lubitz, CD Demmler, J Reuschel, K Bergner, U Marx


2013, Lab on a Chip, Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput
EM Materne, A Tonevitsky, U Marx

Immunocompetent Skin (biopsies) Hair follicles

2013, Lab on a Chip, Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion
B Ataҫ, I Wagner, R Horland, R Lauster, U Marx, A Tonevitsky, A Azar, G Lindner

Cell viability monitoring

2013, Analyst, Fluorescent optical fiber sensors for cell viability monitoring
I Sergachev, A Rusanov, E Trushkin, D Sakharov, U Marx, A Tonevitsky


2011, Sensors and Actuators, Biological cardio-micro-pumps for micro­bio­reactors and analytical micro-systems
M Pilarek, P Neubauer, U Marx


2020, Current Opinion in Toxicology, Journal pre-proof, The universal physiological template – a system to advance medicines
Dehne EM, Marx U

MPS in general

2020, ALTEX, Preprint, Biology-inspired Microphysiological systems to advance patient benefit and animal welfare in drug development
Marx U, Akabane T, Andersson T, Baker E, Beilmann M, Beken S, Brendler-Schwaab S, Cirit M, David R, Dehne EM, Durieux I, Ewart L, Fitzpatrick S, Frey O, Fuchs F, Griffith L, Hamilton G, Hartung T, Hoeng J, Hogberg H, Hughes D, Ingber D, Iskandar A, Kanamori T, Kojima H, Kuehnl J, Leist M, Li B, Loskill P, Mendrick D, Neumann T, Pallocca G, Rusyn I, Smirnova L, Steger-Hartmann T, Tagle D, Tonevitsky A, Tsyb S, Trapecar M, van de Water B, van den Eijnden-van Raaij J, Vulto P, Watanabe K, Wolf A, Zhou X, Roth A

2020, Elsevier, 429-439, Human body-on-a-chip systems in: Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing
Dehne EM, Marx U

2019, Elsevier, 279-284, Biologically-Inspired Microphysiological Systems in: The History of Alternative Test Methods in Toxicology
Dehne EM, Hickman J & Shuler M

2018, ALTEX, Optimizing drug discovery by Investigative Toxicology: Current and future trends
Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T,Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T

2017, Annu Rev Pharmacol Toxicol., Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery
Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, Ingelman-Sundberg M, Jang KJ, Jones DR, Lauschke VM, Marx U, Mettetal JT, Pointon A, Williams D, Zimmermann WH, Newham P

2017, LABO Online, Von der Vision zum Paradigmenwechsel: Chancen und Herausforderungen mikrofluidischer Organ-on-a-Chip-Systeme in der Arzneimittelentwicklung
Dehne EM, Hasenberg T, Marx U

2017, BIOspektrum, Miniaturisierte menschliche Organe auf dem Chip
Hasenberg T, Dehne EM, Lauster R, Marx U

2017, Future Science, The ascendance of microphysiological systems to solve the drug testing dilemma
Dehne EM, Hasenberg T, Marx U

2016, Advances in Experimental Medicine and Biology, Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment
Rebelo SP, Dehne EM, Brito C, Horland R, Alves PM, Marx U

2016, ALTEX, Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing = ALTEX Award Winner 2017!
Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A

2015, Applied In Vitro Toxicology, The promise and potential of "Organs-on-Chips" as preclinical models
A Bahinski, R Horland, D Huh, C Mummery, DA Tagle, T MacGill

2012, Alternatives to Lab Animals, 'Human-on-a-chip' developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?
U Marx, H Walles, S Hoffmann, G Lindner, R Horland, F Sonntag, U Klotzbach, D Sakharov, A Tonevitsky, R Lauster

2012, Biotechnology Journal, Monitoring and control of microbioreactors: an expert opinion on development needs
KV Gernaey, F Baganz, E Franco-Lara, F Kensy, U Krühne, M Luebberstedt, U Marx, E Palmqvist, A Schmid, F Schubert, CF Mandenius

2012, Landes Bioscience and Springer Science + Business Media, "Trends in Cell Culture Technology." In Balls M, Combes R, & Bhogal, N, New Technologies for Toxicity Testing (26-46)
U Marx

2011, BIOspektrum, Miniaturisierte humane organtypische Zell- und Gewebekulturen
F Sonntag, M Gruchow, I Wagner, G Lindner, U Marx

2010, Journal of Biotechnology, Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure
F Sonntag, N Schilling, K Mader, M Gruchow, U Klotzbach, G Lindner, R Horland, I Wagner, R Lauster, S Howitz, S Hoffmann, U Marx

Tissue cultures

2010, BIOforum Europe, Organotypic tissue cultures for substance testing
R Pörtner, C Burger, K Maier-Reif, C Goepfert, S Hoffmann, A Scriba, U Marx