Publikationen – Sicherheit

2024, Food and Chemical Toxicology, Vol. 193, Hepatotoxic assessment in a microphysiological system: Simulation of the drug absorption and toxic process after an overdosed acetaminophen on intestinal-liver-on-chip
Yu Y, Sun B, Ye X, Wang Y, Zhao M, Song J, Geng X, Marx U, Li B, Zhou X

2023, Frontiers in Pharmacology, Vol. 14, Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions
Tao TP, Maschmeyer I, LeCluyse EL, Rogers E, Brandmair K, Gerlach S, Przibilla J, Kern F, Genies C, Jacques C, Najjar A, Schepky A, Marx U, Kühnl J, Hewitt NJ

2023, ALTEX, A microfluidic thyroid-liver platform to assess chemical safety in humans
Kühnlenz J, Karwelat D, Steger-Hartmann T, Raschke M, Bauer S, Vural Ö, Marx U, Tinwell H, Bars R

2022, Frontiers in Toxicology, A Multi-Organ-on-Chip Approach to Investigate How Oral Exposure to Metals Can Cause Systemic Toxicity Leading to Langerhans Cell Activation in Skin
Koning JJ, Rodrigues Neves CT, Schimek K, Thon M, Spiekstra SW, Waaijman T, de Gruijl TD, Gibbs S

2021, Journal of Applied Toxicology, Early view, Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model
Tao TP, Brandmair K, Gerlach S, Przibilla J, Géniès C, Jacques‐Jamin C, Schepky A, Marx U, J. Hewitt N, Maschmeyer I, Kühnl J

2021, Toxicology, Vol. 448, Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model
Kühnl J, Tao TP, Brandmair K, Gerlach S, Rings T, Müller-Vieira U, Przibilla J, Genies C, Jaques-Jamin C, Schepky A, Marx U, J. Hewitt N, Maschmeyer I

2020, Scientific reports. Vol. 10, Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents
Lin N, Zhou X, Geng X, Drewell C, Hübner J, Li Z, Zhang Y, Xue M, Marx U, Li B

2020, International Journal of Pharmaceutics, Vol. 589, Toxicity of topically applied drugs beyond skin irritation: Static skin model vs. Two organs-on-a-chip
Tavares RSN, Tao TP, Maschmeyer I, Maria-Engler SS, Schäfer-Korting M, Winter A, Zoschke C, Lauster R, Marx U, Gaspar LR

2020, Advanced Science, Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow
Schoon J, Hesse B, Rakow A, Ort MJ, Lagrange A, Jacobi D, Winter A, Huesker K, Reinke S, Cotte M,Tucoulou R, Marx U, Perka C, Duda GN, Geissler S

2020, Human Reproduction, Vol. 35, A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model
Baert Y, Ruetschle I, Cools W, Oehme A, Lorenz A, Marx U, Goossens E, Maschmeyer I

2020, Scientific Reports, Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies
Schimek K, Frentzel S, Luettich K, Bovard D, Rütschle I, Boden L, Rambo F, Erfurth H, Dehne EM, Winter A, Marx U, Hoeng J

2020, Elsevier, 429-439, Human body-on-a-chip systems in: Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing
Dehne EM, Marx U

2018, ALTEX, Optimizing drug discovery by Investigative Toxicology: Current and future trends
Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T,Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T

2018, Nature Scientific Reports, Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model
Hübner J, Raschke M, Rütschle I, Gräßle S, Hasenberg T, Schirrmann K, Lorenz A, Schnurre S, Lauster R, Maschmeyer I, Steger-Hartmann T, Marx U

2017, Annu Rev Pharmacol Toxicol., Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery
Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, Ingelman-Sundberg M, Jang KJ, Jones DR, Lauschke VM, Marx U, Mettetal JT, Pointon A, Williams D, Zimmermann WH, Newham P

2015, European Journal of Pharmaceutics and Biopharmaceutics, Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro
I Maschmeyer, T Hasenberg, A Jaenicke, M Lindner, AK Lorenz, J Zech, LA Garbe, F Sonntag, P Hayden, S Ayehunie, R Lauster, U Marx, EM Materne

2015, Journal of Visualized Experiments, The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
EM Materne, I Maschmeyer, AK Lorenz, R Horland, K Schimek, M Busek, F Sonntag, R Lauster, U Marx

2015, Journal of Biotechnology, A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing
EM Materne, AP Ramme, A Terrasso, M Serra, P Alves, C Brito, D Sakharov, A Tonevitsky, R Lauster, U Marx

2013, Lab on a Chip, Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput
EM Materne, A Tonevitsky, U Marx

2013, Lab on a Chip, A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
I Wagner, EM Materne, S Brincker, U Süßbier, C Frädrich, M Busek, F Sonntag, D Sakharov, E Trushkin, A Tonevitsky, R Lauster, U Marx