Publikationen – Haut

2023, Journal of Applied Toxicology, Early View, Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein
Tao TP, Brandmair K, Gerlach S, Przibilla J, Schepky A, Marx U, Hewitt NJ, Maschmeyer I, Kühnl J

2023, Journal of Applied Toxicology, Early View, Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene
Brandmair K, Tao TP, Gerlach S, Przibilla J, Schepky A, Marx U, Hewitt NJ, Kühnl J, Maschmeyer I

2023, Frontiers in Pharmacology, Vol. 14, Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions
Tao TP, Maschmeyer I, LeCluyse EL, Rogers E, Brandmair K, Gerlach S, Przibilla J, Kern F, Genies C, Jacques C, Najjar A, Schepky A, Marx U, Kühnl J, Hewitt NJ

2022, Pharmaceutics, Vol. 14, Proof-of-Concept Organ-on-Chip Study: Topical Cinnamaldehyde Exposure of Reconstructed Human Skin with Integrated Neopapillae Cultured under Dynamic Flow
Vahav I, Thon M, van den Broek LJ, Spiekstra SW, Ataҫ B, Lindner G, Schimek K, Marx U, Gibbs S

2022, Frontiers in Toxicology, A Multi-Organ-on-Chip Approach to Investigate How Oral Exposure to Metals Can Cause Systemic Toxicity Leading to Langerhans Cell Activation in Skin
Koning JJ, Rodrigues Neves CT, Schimek K, Thon M, Spiekstra SW, Waaijman T, de Gruijl TD, Gibbs S

2021, Journal of Applied Toxicology, Early view, Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model
Tao TP, Brandmair K, Gerlach S, Przibilla J, Géniès C, Jacques‐Jamin C, Schepky A, Marx U, J. Hewitt N, Maschmeyer I, Kühnl J

2021, Toxicology, Vol. 448, Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model
Kühnl J, Tao TP, Brandmair K, Gerlach S, Rings T, Müller-Vieira U, Przibilla J, Genies C, Jaques-Jamin C, Schepky A, Marx U, J. Hewitt N, Maschmeyer I

2020, International Journal of Pharmaceutics, Vol. 589, Toxicity of topically applied drugs beyond skin irritation: Static skin model vs. Two organs-on-a-chip
Tavares RSN, Tao TP, Maschmeyer I, Maria-Engler SS, Schäfer-Korting M, Winter A, Zoschke C, Lauster R, Marx U, Gaspar LR

2020, Journal of Tissue Engineering and Regenerative Medicine, Vol. 14, Reconstructed human skin shows epidermal invagination towards integrated neopapillae indicating early hair follicle formation in vitro
Vahav I, van den Broek LJ, Thon M, Monsuur HN, Spiekstra SW, Atac B, Scheper RJ, Lauster R, Lindner G, Marx U, Gibbs S

2018, Nature Scientific Reports, Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model
Hübner J, Raschke M, Rütschle I, Gräßle S, Hasenberg T, Schirrmann K, Lorenz A, Schnurre S, Lauster R, Maschmeyer I, Steger-Hartmann T, Marx U

2018, Bioengineering 2018, Bioengineering of a Full-Thickness Skin Equivalent in a 96-Well Insert Format for Substance Permeation Studies and Organ-on-a-Chip Applications
Schimek K, Hsu HH, Boehme M, Kornet JJ, Marx U, Lauster R, Pörtner R, Lindner G

2018, J Vis Exp., A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
Hsu HH, Kracht JK, Harder LE, Rudnik K, Lindner G, Schimek K, Marx U, Pörtner R

2015, ALTEX, Workshop Report: Non-Animal Models of Epithelial Barriers (Skin, Intestine and Lung) in Research, Industrial Applications and Regulatory Toxicology
S Gordon, M Daneshian, J Bouwstra, F Caloni, S Constant, DE Davies, G Dandekar, CA Guzman, E Fabian, E Haltner, T Hartung, N Hasiwa, P Hayden, H Kandarova, S Khare, HF Krug, C Kneuer, M Leist, G Lian, U Marx, M Metzger, K Ott, P Prieto, MS Roberts, EL Roggen, T Tralau, C van den Braak, H Walles

2015, Lab on a Chip, A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
I Maschmeyer, AK Lorenz, K Schimek, T Hasenberg, AP Ramme, J Hübner, M Lindner, C Drewell, S Bauer, A Thomas, NS Sambo, F Sonntag, R Lauster, U Marx

2015, European Journal of Pharmaceutics and Biopharmaceutics, Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro
I Maschmeyer, T Hasenberg, A Jaenicke, M Lindner, AK Lorenz, J Zech, LA Garbe, F Sonntag, P Hayden, S Ayehunie, R Lauster, U Marx, EM Materne

2015, Journal of Visualized Experiments, The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
EM Materne, I Maschmeyer, AK Lorenz, R Horland, K Schimek, M Busek, F Sonntag, R Lauster, U Marx

2013, Lab on a Chip, A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
I Wagner, EM Materne, S Brincker, U Süßbier, C Frädrich, M Busek, F Sonntag, D Sakharov, E Trushkin, A Tonevitsky, R Lauster, U Marx

2013, Lab on a Chip, Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion
B Ataҫ, I Wagner, R Horland, R Lauster, U Marx, A Tonevitsky, A Azar, G Lindner